![]() Usher syndrome type 1 is characterized by severe to profound hearing loss in both ears at birth (congenital deafness) and balance problems. These narrowed visual fields are also referred to as “tunnel vision.” Issues with balance are seen mainly in individuals with Usher syndrome types 1 and 3, although balance difficulties in Usher syndrome type 2 have been reported. Studies show that clear central vision may be maintained for many years even while side (peripheral) vision decreases. The vision loss caused by RP may begin during childhood or later during life, and often first presents with difficulty seeing at night or in low light (“night blindness”). Sensorineural hearing loss may be profound or mild and may be progressive. RP eventually causes retinal degeneration leading to progressive loss of vision and legal blindness. Usher syndrome is characterized by deafness due to an impaired ability of the inner ear and auditory nerves to transmit sensory (sound) input to the brain (sensorineural hearing loss) as well as abnormal accumulation of colored (pigmented) material on the nerve-rich membrane (the retina) lining the eyes (retinitis pigmentosa or RP). ![]() Stay Informed With NORD’s Email Newsletter.Find a Rare Disease Patient Organization.Rare Disease Cures Accelerator (RDCA-DAP).Find Clinical Trials & Research Studies.Launching Registries & Natural History Studies.A Podcast For The Rare Disease Community.The work will provide a solid foundation for understanding the function of each usherin isoform and developing an effective gene therapy platform to treat USH2A associated visual defects, she said. ![]() “Understanding which isoforms of usherin are expressed in the retina and the cochlea and what role they play (in contrast to mutant pathogenic forms) is essential in developing an effective gene therapy construct,” Naash said. Naash has already cloned two usherin isoforms to be tested with her innovative platform to safely advance gene therapy for USH2A. To rescue vision loss, Naash’s non-viral therapy targets the mutation in usherin, the protein product that causes Usher Syndrome Type 2A. “Developing an effective treatment for USH2A has been challenging due to its large coding sequence (15.8 kb) that has precluded its delivery using standard approaches and the presence of multiple isoforms with functions that are not fully understood,” said Naash, who will also evaluate the long-term efficacy of the best therapeutic platform for future translation to the clinic. Intravitreal treatment consists of injections directly into the vitreal chamber of the eye. Gene therapy is the introduction of a normal gene into cells to correct genetic disorders. “Our goal is to advance our current intravitreal gene therapy platform consisting of DNA nanoparticles/hyaluronic acid nanospheres to deliver large genes in order to develop safe and effective therapies for visual loss in Usher Syndrome Type 2A,” Naash said. RP affects the retina, the eye’s light-sensitive layer, leading to a breakdown of cells in the retina which causes blindness. Usher Syndrome Type 2A, caused by mutations of the USH2A gene, can include hearing loss from birth and progressive loss of vision, prompting retinitis pigmentosa (RP). ![]() Dunn Endowed Professor of biomedical engineering, $1.6 million to support her work. The National Eye Institute has awarded Muna Naash, John S. Engineering Program for Innovation and Entrepreneurship (EPIE)Ī University of Houston researcher is expanding a method of gene therapy with the hopes it will restore vision loss in Usher Syndrome Type 2A (USH2A), a rare genetic disease.Virtual Institutes for Cyber and Electromagnetic Spectrum Research and Employ (VICEROY).How to Engineer Your Future, Admissions & More.
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![]() ![]() “JixiPix turns any photo into a masterpiece. ‘Like us on facebook’ for tips & tricks, quick announcements and interaction with the Jixi team! The Premium Pack includes 18 Appsin one powerful package The Premium Pack comes with 18 incredible Apps rolled into one interface for ease of use: Aquarella, Artista Haiku, Artista Oil, Artista Sketch, Artoon, Chalkspiration, Dramatic Black&White, Grungetastic, Kyoobik Photo, Moku Hanga, NIR Color, Pop Dot Comics, Portrait Painter, Rainy Daze, Romantic Photo, Simply HDR, Snow. Our mobile version can Email, Print, and post directly to Facebook, Instagram, Twitter, and Tumblr. 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Standalone Product that transform photos into paintings then combines paint effects with layers and brushes for gorgeous print-worthy artwork.Make a Black and White Photo with Light Contrast Grit and Form Artista Impresso is a professional painting app created for photographers and artists of all skill levels INCLUDES. The actual developer of this software for Mac is JixiPix Software, LLC. The software is categorized as Design & Photo Tools. The file size of the latest downloadable installer is 130.2 MB. Pro Version Includes: Smart Layers, Brushes, Painted Edges and 6 Paint Styles: Alla Prima, En Plein Air, Soft Paint, Background Paint, Aged Paint and Tache. Download Artista Impresso Pro 1.8.19 for Mac from our software library for free. Impresso Pro has everything an Artist or Photographer will need to create gallery-style paintings with enough detail even for the largest print. JixiPix Artista Impresso Pro 1.8.24 macOS | 120.9 MB | įor professionals who like creative control we give you Smart Layers and brushes for blending multiple paint styles, a library of Edges that blend beautifully with canvas, a Background Paint effect to create distances, a Soft Paint effect for enhancing foreground subjects, an Aged Paint effect for adding craquelure to paintings, and an ultra-impressionism effect called Tache to cover paintings with broken brush strokes. ![]() German chocolate cake was invented by a Texan who used “German’s Chocolate” which is simply baking chocolate named after the creator, Sam German. German chocolate cake has nothing to do with Germany.The name was coined in the 50’s by a cook who was trying not to curse in front of kids. ![]() Considered to be Mexican food, chimichangas actually originated from Tucson, Arizona. In South Africa, it’s more common for what they call popcorn, to be roasted termites and ants. But, if you cook them thoroughly, you’ll be just fine! Raw lima beans have lethal amounts of cyanide in them. Although the inside is the best part and we’re always excited to get a solid bite of that fluffy goodness, it’s actually vegetable shortening! However, one study conducted determined the average was 364 licks! It’s a heavily debated topic – exactly how many licks does it take to get to the center of a tootsie pop? It can take anywhere from 144 to 411 licks.
Linked Accounts for Big Servers: If you want to join the big parties like Hypixel or Mineplex, TLauncher says, "Sure thing!" Link your Minecraft account to TLauncher, and you can jump into the fun with everyone else.TLauncher lets you do that, but it depends on where you want to play: The multiplayer part of Minecraft is like having friends over to play together. No more missing out on the cool updates!Ĭan TLauncher players play with real Minecraft players? It connects you to Mojang’s servers, so you're always in the loop with what's happening in the Minecraft universe. Stay Connected – Online Mode: TLauncher is your passport to the latest Minecraft party.Pick and choose to make your Minecraft character stand out. TLauncher has a catalog full of armor, clothes, skins, and more. Catalog for Your Minecraft Wardrobe: It's like having your own fashion store in Minecraft.So, you're never left wondering, "What does this button do?" 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Switch Versions Easily: TLauncher lets you hop between different versions of Minecraft.Let's take a closer look at the cool stuff it brings to your Minecraft world: TLauncher is like a treasure chest of features that make Minecraft more exciting. It also comes with a range of customization options for an enhanced gaming experience. It’s not only user-friendly, but also lets players create their own armor, maps, skins, and mods. One of the best parts about downloading TLauncher is that it opens up various avenues for users who like playing Minecraft. As mentioned before, the launcher is a cracked version that lets you play offline, as well as in multiplayer mode in a local network. However, if you’ve already bought the official video game, you won’t be able to play it along with TLauncher. While TLauncher doesn’t have the Mojang license, it still is one of the most popular Minecraft launchers available in the market. In case you don’t have an account, you can sign up using your email address and create a password. It’s also quite lightweight and lets users log in to the platform using their official Minecraft account. ![]() In addition to this, the application lets users design maps, battles, skins, mods, and characters, among other options. ![]() It’s very popular because it lets users play any version of the creative sandbox game. TLauncher is a cracked version of the official video game Minecraft. ![]() The sheathing on most buildings is actually the bracing element. There is an opportunity for more trig and geometry there The posts and beams become long levers around that fulcrum. If you look at post framed buildings, engineered pole barns, there are brace bays where they make a large X using threaded rod and turnbuckles from the bottoms of the posts up to the plate level. As a brace gets shorter it applies side load to the post and also begins to jack the plate off the post in a racking situation. There is structurally no such thing as too long, ideally from floor at one post to plate at the next is good. In a racking situation one of the pair goes into tension, the other is in compression. Like you just did with Pythagoras, you can use that to find the line length ratio of any right triangle.īraces are installed as pairs whenever possible because in wood they are really only effective in compression. Yeah, they should be taught in shop class rather than by a bored teacher who cannot answer the question "what is this stuff good for?"įor a right triangle with equal length legs, that is 45 degree angles (or a 12/12 roof), the magic numbers, carpenters call them line length ratios, to have etched into your brain are. Well, I've discussed what size, and what length, and how many really is a frame specific question. I think I have posted this information before on the "framing square" story thread, but maybe not. And good companies have continued making these framing squares with these numbers on them. These lengths were considered standard lengths by the framing square manufacturer so I'd have to assume that they were standard lengths used by timber framers who informed the square makers that they needed this information for their layout. So the diagonal measurement of the 24" x24" brace layout is 33 15/16". The answer is 15.04, rounding off to the nearest 16, that's 15/16ths. 94 times 16 and you get the number of 16ths. 94 to a fraction so that you can lay it out with your tape measure you multiply the. For example, next to the 24-24 layout is 33.94 so that's 33.94" to convert the. Also, on the framing square next to these numbers, is the diagonal dimension of the brace layout, as a decimal number. These are the spacing lengths of the two legs of the right triangle of the brace layout. On a regular framing square, a good one, and not necessarily an old one, on the tongue, you'll find some brace layout lengths. If the brace is too long then it will interfere with the door and windows, make it shorter so that it won't. What length? Well again, placement come into play. However in very large timber frames for very large barns sometimes 6圆 or even 6x8 braces are used. Mostly I've seen either 4圆 or 3x5 inch braces. You need to think about the placement of everything and how it will effect everything else. In the second window which was way up high in this house, you may not need a curtain but you'll still have trouble cutting and installing the trim boards. How are you going to trim that window out with wood? How are you going to hang a curtain in front of that window? In the first photo not only the brace is in front of the window but the timber the brace is hooked to is also in front of the window. In both of these photos, you can see that the house was under construction. I have posted these pictures before, at least I thought I did, but here are two examples of what I mean: That means proper planning of every door and window location in advance. ![]() To properly place braces you have to take into consideration window and door locations so that the braces don't interfere with the doors and windows. But this can be too extreme and you may end up with interior posts having braces on all four faces. What that means is between every pair of posts in both directions left and right and front and back. One timber framer near me, puts them in every rectangular opening of the frame. You should have them in every exterior wall surface, at least at every corner as a minimum. ![]() Each brace has an opposing opposite brace, in the same plane of the frame. First rule of braces is that you can't have just one, they come in pairs. ![]() Customize your G703 Wireless Mouse to match your room or your other desk accessories. Give this performance mouse the pop of color it deserves. Logitech G703 Lightspeed Pro-Grade Wireless Gaming Mouse, 16000 DPI, RGB, Adjustable Weights, 6 Programmable Buttons, On-Board Memory, Long Battery Life, PC/Mac. Exceptionally precise and consistent, used by eSports pros worldwide. Become more accurate than you’ve ever been before with the world’s most advanced gaming mouse sensor. The G703 wireless mouse is built for gaming speed, accuracy and endurance. Customize your sleek desk accessory with a vibrant new color combination. Now ColorWare brighten up your mouse with a touch of style. Or Contact our Customer Service Team using the Contact Us Form.The Logitech G703 Wireless Gaming Mouse combines gaming performance and comfort. Questions? You can refer to the FAQ here. Installation/Dismantling cost and any other 3rd party cost applies separately. Delivery will be facilitated by Harvey Norman.ĭelivery cost does not include installation/dismantling. Large / Bulky Items: Delivery estimate of 7-14 Working days from the date of your order. Delivery will be facilitated by SingPost and local couriers. Excluding Saturday, Sunday and Public Holidays. Small Items: Delivery estimate of 2-7 Working days from the date of your order. Self collection ONLY applies for selected Small Items. Or 2-4 Working days for orders made on Public Holidays, Saturday and Sunday. Discover more about the small businesses partnering with Amazon and Amazon’s commitment to. Shop products from small business brands sold in Amazon’s store. Self Collect: Ready for collection within 1-3 Working days from the date of your order notification confirmation. 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Get ready for next-level tracking, enhanced LIGHTSPEED, and 10X the power efficiency of the previous generation. ![]() G703 LIGHTSPEED enters the next generation of performance with the advanced HERO 16K sensor. ![]() ![]() Walnut often features a smooth surface ranging from light, pale brown to a dark chocolate colour. Walnut is a timber subspecies used within the architecture and construction industry, favoured for its adaptability. The image represents a physical area of 3200 x 2260 mm (126 x 89 inches) in total. Animation: Apple recommends animations no longer than 10 seconds.A seamless wood texture with a walnut surface.Apple recommends no more than 100k for the best performance. The limit is not clearly defined yet, but 500k seems to be a good rule of thumb. Vertex/Polygon count: some models cannot be loaded because they have too many vertices/faces.Apple recommends textures no bigger than 2048×2048 pixels for best performance. Downsizing textures may make them work, but the actual limitation is unknown for now. Textures: models with large textures or many textures will not load.Please visit Viewer Performance to learn more.Īpple also offers the following USDZ-specific performance considerations: These considerations are even more important for mobile devices, especially in AR mode. Much like the Sketchfab viewer, the load time and performance of the 3D model depends on a lot of factors like the number of polygons in the mesh and the size of textures. USDZ does not support the Alpha Mask channel.This is not an issue for models that are closed volumes, but it will not work well when models have planes or faces that can be visible from both sides. Double sided rendering is not supported, so all models are rendered single sided.All textures will be mapped using the first UV channel. Multiple UV channels are not supported.Animations will loop endlessly in Quick Look. Animation loop modes are not supported.Vertex Colors are not supported, so models that depend on Vertex Colors will not look correct.A workaround could be to duplicate the base color texture in the emission channel. Quick Look does not have a Shadeless mode, so 3D scans and other models set to Shadeless may look darker than expected.Point Clouds are not available in USDZ.For a more exhaustive list, please visit Google's USD from glTF compatibility documentation. Here are some key Sketchfab features that are not supported by USDZ / AR Quick Look. The USDZ format and Apple's AR Quick Look have additional limitations. Since the USDZ file is generated based on the glTF file, anything unsupported by glTF will not be supported by USDZ. Maximum number vertex attributes per mesh is often set to 16, which can be especially problematic for morph target animations.Multiple UVs - some engines may force every channel to use the same Texture Coordinates.Some features are supported by the glTF format itself, but not by certain engines like Unity or Three.js (e.g. Refraction, Dithered, and Additive transparency (will be converted to Blending).Some shaders and features are not supported by the glTF specification, so they will not be exported. If you upload a model with 8k textures, all three versions will be generated. For example, if you upload a model with source textures that are only 512×512 px, we will only generate a GLB with the original textures. We only generate each version when necessary. We also generate several versions of GLB with different maximum texture resolutions: Then, we convert that glTF file into a USDZ file with as much of the same data as possible. Sketchfab takes your original 3D data (meshes, objects, animations, etc.) combined with all the material information in 3D Settings, and converts it to the glTF format using PBR materials and textures. You can also import models directly into your 3D software using Importers. ![]() The news of the violent circumstances surrounding Harris’ death rocked Monroe, where Union Academy had issued a statement just two days earlier calling on students to wear school colors to celebrate Harris. Stewart, who had apparently fled following the firefight, was found at his home with “related objects tied to the crime scene” and charged with first-degree burglary and first-degree murder, police said. Deputies found a bag with 1.2 kilos of cocaine and about $7,000 in cash near Lara’s body. “They were looking for money or drugs, or both,” he said. ![]() “The trailer looked like it had been ransacked,” the sheriff said. Deputies did not disclose who they believe shot Lara, and the investigation is ongoing. Officers brought him to a nearby hospital, where he died. Lara’s hands and feet were bound, and he was shot “execution-style,” the sheriff said, though he was still clinging to life when police got there. When police officers discovered the grisly scene after reports of gunfire in the mobile home, they found Harris’ body as well as Lara’s, the cartel member the two had allegedly plotted to rob. “The I-85 and I-40 corridor has really caused Alamance County to be a great place to deposit their drugs,” the sheriff said of the cartel’s growing presence in the area. He was found in the stash house wearing a bulletproof vest, gloves, and a face cover, the sheriff said. Harris, 40, seemed to have come prepared for a fight. Harris, who taught Spanish at Union Academy Charter School and served as the boys’ head basketball coach, was found dead last week in a mobile home belonging to the Jalisco New Generation Cartel, widely considered to be the most powerful and ruthless drug cartel in Mexico, Alamance County Sheriff Terry Johnson announced at a Wednesday press conference. They fondly recalled his uplifting “all love, no fear” motto, the “encouragement and motivation” he gave to students at his school, and his smile that “will forever remain etched in our hearts.”īut two days later, the local sheriff dropped a bombshell: teacher Barney Dale Harris had died while allegedly trying to rob a Mexican drug cartel. Students and parents alike joined in mourning the sudden death of a popular high school basketball coach earlier this week in Monroe, North Carolina. Apple or its trade-in partners reserve the right to refuse or limit quantity of any trade-in transaction for any reason. Some stores may have additional requirements. Offer may not be available in all stores, and may vary between in-store and online trade-in. In-store trade-in requires presentation of a valid photo ID (local law may require saving this information). Sales tax may be assessed on full value of a new device purchase. Actual value awarded is based on receipt of a qualifying device matching the description provided when estimate was made. Trade-in value may be applied toward qualifying new device purchase, or added to an Apple Gift Card. You must be at least 18 years old to be eligible to trade in for credit or for an Apple Gift Card. Trade-in values will vary based on the condition, year, and configuration of your eligible trade-in device.territories, please call Goldman Sachs at 877‑255‑5923 with questions about Apple Card. Apple Card is subject to credit approval, available only for qualifying applicants in the United States, and issued by Goldman Sachs Bank USA, Salt Lake City Branch. To access and use all Apple Card features and products available only to Apple Card users, you must add Apple Card to Wallet on an iPhone or iPad that supports and has the latest version of iOS or iPadOS. See the Apple Card Customer Agreement for more information about ACMI financing. ![]() ![]() See /kb/HT211204 for information about upcoming changes to ACMI financing. ACMI financing is subject to change at any time for any reason, including but not limited to, installment term lengths and eligible products. The last month’s payment for each product will be the product’s purchase price, less all other payments at the monthly payment amount. ACMI is not available for purchases made online at the following special stores: Apple Employee Purchase Plan participating corporate Employee Purchase Programs Apple at Work for small businesses Government, and Veterans and Military Purchase Programs, or on refurbished devices. An iPhone purchased with ACMI is always unlocked, so you can switch carriers at any time. You’ll need to select AT&T, T‑Mobile, or Verizon as your carrier when you check out. Taxes and shipping on ACMI purchases are subject to the variable APR, not 0% APR. If you buy an ACMI eligible product by choosing to pay in full with Apple Card (instead of using ACMI), that purchase is subject to the Apple Card variable APR, not 0% APR. ![]() Existing cardholders: See your Customer Agreement for applicable rates and fee. Cardholders who accept an Apple Card on and/or after August 10, 2023: Variable APRs for Apple Card, other than ACMI, range from 19.24% to 29.49% based on creditworthiness. APR ranges may vary based on when you accepted an Apple Card. ![]() See /kb/HT211204 for more information about eligible products. for eligible Apple products purchased at Apple Store locations,, the Apple Store app, or by calling 1‑800‑MY‑APPLE, and is subject to credit approval and credit limit. Pricing shown for iPhone 14 and iPhone 14 Plus includes a $30 connectivity discount for Verizon and T‑Mobile customers that requires activation and would otherwise be $30 higher for all other customers.Īpple Card Monthly Installments (ACMI) is a 0% APR payment option that is only available if you select it at checkout in the U.S.
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